OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACID pH - Patent 0690716

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EP 0 690 716 A1

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(43)	Date of publication:
	10.01.1996 Bulletin 1996/02

(21)	Application number: 94906041.0

(22)	Date of filing: 05.01.1994

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International Patent Classification (IPC):

C07H 21/ 04^{( . )}
A61P 31/ 12^{( . )}
C07H 21/ 00^{( . )}

A61K 31/ 70^{( . )}
A61P 35/ 00^{( . )}

(86)	International application number:
	PCT/US1994/000157

(87)	International publication number:
	WO 1994/015619 (21.07.1994 Gazette 1994/17)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

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Priority:

06.01.1993 US 19930001109

(71)	Applicants:
	THE JOHNS HOPKINS UNIVERSITY Baltimore, MD 21218-2692 (US) GENTA INCORPORATED San Diego, California 92121 (US)

(72)	Inventors:
	MILLER, Paul, Scott Baltimore, MD 21212 (US) TS'O, Paul, On-Pong Ellicott City, MD 21043 (US) SIMON, Lionel, Norton Solana Beach, CA 92075 (US)

(74)	Representative: Patentanwälte Viering, Jentschura & Partner
	Postfach 22 14 43 D-80504 München D-80504 München (DE)

(54)	OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACID pH