(19)

(11)

EP 0 690 917 A1

(12)

(43) Date of publication: 10.01.1996 Bulletin 1996/02 (21) Application number: 94911554.0 (22) Date of filing: 11.03.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 31/ 12( . ) C12N 5/ 10( . ) A61K 39/ 00( . ) C12R 1/ 92( . ) A61K 39/ 245( . ) C07K 14/ 05( . ) C12P 21/ 02( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1994/002637 (87) International publication number: WO 1994/020138 (15.09.1994 Gazette 1994/21)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 12.03.1993 US 19930031186 (71) Applicant: THERATECH, INC. Salt Lake City Utah 84108 (US)	(72) Inventor: PRAKASH, Ramesh Salt Lake City, UT 84124 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)