(19)

(11)

EP 0 691 844 A1

(12)

(43) Date of publication: 17.01.1996 Bulletin 1996/03 (21) Application number: 94909883.0 (22) Date of filing: 29.03.1994

(51) International Patent Classification (IPC):  A61K 45/ 00( . ) A61K 31/ 7016( . ) A61K 31/ 715( . ) A61K 31/ 795( . ) A61K 47/ 48( . ) A61P 3/ 10( . ) A61P 25/ 28( . ) C07H 11/ 00( . ) A61K 31/ 185( . ) A61K 31/ 7024( . ) A61K 31/ 737( . ) A61K 38/ 00( . ) A61L 33/ 08( . ) A61P 25/ 00( . ) A61P 43/ 00( . ) C07H 15/ 04( . ) (86) International application number: PCT/CA1994/000160 (87) International publication number: WO 1994/022437 (13.10.1994 Gazette 1994/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.03.1993 US 19930037844 (60) Divisional application: 00202287.9 / 1060750 (60) Divisional application: 05022113.4 / 1614416 (71) Applicant: QUEEN'S UNIVERSITY AT KINGSTON Kingston Ontario K7L 3N6 (CA)	(72) Inventors: KISILEVSKY, Robert Kingston, Ontario K7M 4B9 (CA) SZAREK, Walter, A. Kingston, Ontario K7L 1S9 (CA) WEAVER, Donald Kingston, Ontario K7M 7J8 (CA) (74) Representative: Simpson, Alison Elizabeth Fraser, et al  Urquhart-Dykes & Lord, 91 Wimpole Street London W1M 8AH London W1M 8AH (GB)