(19)

(11)

EP 0 691 976 A1

(12)

(43) Date of publication: 17.01.1996 Bulletin 1996/03 (21) Application number: 94909884.0 (22) Date of filing: 29.03.1994

(51) International Patent Classification (IPC):  A61K 31/ 185( . ) A61K 31/ 795( . ) A61L 33/ 08( . ) C07H 15/ 04( . ) A61K 31/ 737( . ) A61K 47/ 48( . ) C07H 11/ 00( . ) (86) International application number: PCT/CA1994/000161 (87) International publication number: WO 1994/022885 (13.10.1994 Gazette 1994/23)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.03.1993 US 19930037844 24.02.1994 US 19940201861 (71) Applicant: QUEEN'S UNIVERSITY AT KINGSTON Kingston Ontario K7L 3N6 (CA)	(72) Inventors: KISILVESKY, Robert Kingston, Ontario K7M 4B9 (CA) SZAREK, Walter, A. Kingston, Ontario K7L 1S9 (CA) GILES, Alan, R. Kingston, Ontario K7L 4B9 (CA) NESHEIM, Michael, E. Kingston, Ontario K7L 3P6 (CA) (74) Representative: Simpson, Alison Elizabeth Fraser, et al  Urquhart-Dykes & Lord, 91 Wimpole Street London W1M 8AH London W1M 8AH (GB)