(19)
(11) EP 0 694 076 A1

(12)

(43) Date of publication:
31.01.1996 Bulletin 1996/05

(21) Application number: 94903250.0

(22) Date of filing: 12.11.1993
(51) International Patent Classification (IPC): 
G01N 33/ 53( . )
A61K 31/ 40( . )
A61K 31/ 445( . )
A61K 38/ 00( . )
A61K 45/ 00( . )
A61P 25/ 28( . )
C07D 207/ 08( . )
C07D 303/ 36( . )
C07D 409/ 12( . )
C07F 9/ 572( . )
C07K 7/ 08( . )
C07K 14/ 81( . )
C12N 9/ 99( . )
G01N 33/ 561( . )
A61K 31/ 385( . )
A61K 31/ 4433( . )
A61K 31/ 675( . )
A61K 38/ 55( . )
A61P 3/ 00( . )
A61P 43/ 00( . )
C07D 211/ 60( . )
C07D 339/ 06( . )
C07D 409/ 14( . )
C07K 7/ 06( . )
C07K 14/ 47( . )
C12N 9/ 64( . )
C12Q 1/ 37( . )
G01N 33/ 68( . )
(86) International application number:
PCT/US1993/010889
(87) International publication number:
WO 1994/013319 (23.06.1994 Gazette 1994/14)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 16.12.1992 US 19920995660

(71) Applicant: Bayer Corporation
Pittsburgh, PA 15219-2502 (US)

(72) Inventors:
  • TAMBURINI, Paul Perry
    Kensington, CT 06037 (US)
  • BENZ, Günter Hans Heinz Herbert
    Guilford, CT 06437 (US)
  • HÄBICH, Dieter
    D-42115 Wuppertal (DE)
  • DREYER, Robert Norman
    Wallingford, CT 06492 (US)

(74) Representative: Dänner, Klaus, Dr. 
Bayer AG Konzernzentrale RP Patente Konzern
D-51368 Leverkusen
D-51368 Leverkusen (DE)

   


(54) CATHEPSIN D IS AN AMYLOIDOGENIC PROTEASE IN ALZHEIMER'S DISEASE