(19)

(11)

EP 0 695 348 A1

(12)

(43) Date of publication: 07.02.1996 Bulletin 1996/06 (21) Application number: 94913051.0 (22) Date of filing: 22.04.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 9/ 20( . ) C12R 1/ 07( . ) C12R 1/ 645( . ) C12R 1/ 685( . ) C12R 1/ 78( . ) C11D 3/ 386( . ) C12N 15/ 55( . ) C12R 1/ 125( . ) C12R 1/ 66( . ) C12R 1/ 69( . ) C12R 1/ 865( . ) (86) International application number: PCT/DK1994/000162 (87) International publication number: WO 1994/025577 (10.11.1994 Gazette 1994/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 23.04.1993 DK 19930000466 (71) Applicant: NOVO NORDISK A/S DK-2880 Bagsvaerd (DK)	(72) Inventors: SVENDSEN, Allan DK-3460 Birkerod (DK) PATKAR, Shamkant, Anant DK-2800 Lyngby (DK) GORMSEN, Erik DK-2830 Virum (DK) CLAUSEN, Ib, Groth DK-3400 Hillerod (DK)