(19)

(11)

EP 0 695 355 A1

(12)

(43) Date of publication: 07.02.1996 Bulletin 1996/06 (21) Application number: 95908381.0 (22) Date of filing: 14.02.1995

(51) International Patent Classification (IPC):  C07K 14/ 52( . ) A61K 38/ 00( . ) C12N 15/ 19( . ) (86) International application number: PCT/JP1995/000208 (87) International publication number: WO 1995/021919 (17.08.1995 Gazette 1995/35)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 14.02.1994 JP 19940039090 25.03.1994 JP 19940079842 01.06.1994 JP 19940155126 15.06.1994 JP 19940167328 17.08.1994 JP 19940193169 17.08.1994 JP 19940227159 18.08.1994 JP 19940193916 01.11.1994 JP 19940304167 01.12.1994 JP 19940298669 28.12.1994 JP 19940341200 (71) Applicant: Kirin Brewery Company, Ltd. Tokyo (JP)

(72) Inventors: MIYAZAKI, Hiroshi Takasaki-shi, Gunma-ken 370 (JP) KATO, Takashi Takasaki-shi, Gunma-ken 370 (JP) OHGAMI, Kinya, 8-102, Shikishima-Ryo Maebashi-shi, Gunma-ken 371 (JP) IWAMATSU, Akihiro, Belvedere A201 Yokohama-shi, Kanagawa-ken 221 (JP) AKAHORI, Hiromichi 3439-78-2, Ishihara-machi Gunma-ken 370 (JP) KUROKI, Ryota 13-20-2, Noukendai 5-chome Yokohama-shi Kanagawa-ken 236 (JP) SHIMIZU, Toshiyuki 35-6-101, Noukendai 6-chome Yokohama-shi Kanagawa-ken 236 (JP) MUTO, Takanori 102, Kanazawahakkei-Ryo Yokohama-shi Kanagawa-ken 236 (JP) (74) Representative: UEXKÜLL & STOLBERG  Patentanwälte Beselerstrasse 4 D-22607 Hamburg D-22607 Hamburg (DE)