(19)

(11)

EP 0 695 357 A1

(12)

(43) Date of publication: 07.02.1996 Bulletin 1996/06 (21) Application number: 94915547.0 (22) Date of filing: 26.04.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61P 31/ 12( . ) C12N 5/ 10( . ) C12P 21/ 02( . ) A61K 39/ 12( . ) C07K 14/ 05( . ) C12N 15/ 38( . ) C12R 1/ 91( . ) (86) International application number: PCT/EP1994/001318 (87) International publication number: WO 1994/025599 (10.11.1994 Gazette 1994/25)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.04.1993 DE 19934313620 (71) Applicant: Wolf, Hans D-93053 Regensburg (DE)	(72) Inventors: WOLF, Hans D-93053 Regensburg (DE) SCHARFENBERG, Klaus D-38124 Braunschweig (DE) WAGNER, Roland D-38124 Braunschweig (DE) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 D-81634 München D-81634 München (DE)