AMIDINO AND GUANIDINO SUBSTITUTED BORONIC ACID INHIBITORS OF TRYPSIN-LIKE ENZYMES

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EP 0 696 199 A1

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(43)	Date of publication:
	14.02.1996 Bulletin 1996/07

(21)	Application number: 94914776.0

(22)	Date of filing: 21.04.1994

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International Patent Classification (IPC):

A61K 38/ 00^{( . )}
A61P 7/ 02^{( . )}
A61P 9/ 10^{( . )}
A61P 43/ 00^{( . )}
C07F 5/ 02^{( . )}
C07K 5/ 065^{( . )}
C07K 5/ 087^{( . )}
C07K 7/ 06^{( . )}

A61P 1/ 00^{( . )}
A61P 9/ 08^{( . )}
A61P 29/ 00^{( . )}
C07D 207/ 16^{( . )}
C07K 5/ 06^{( . )}
C07K 5/ 078^{( . )}
C07K 7/ 02^{( . )}
C07K 7/ 08^{( . )}

(86)	International application number:
	PCT/US1994/004058

(87)	International publication number:
	WO 1994/025049 (10.11.1994 Gazette 1994/25)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

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Priority:

27.04.1993 US 19930052835
02.03.1994 US 19940204055

(71)	Applicant: THE DU PONT MERCK PHARMACEUTICAL COMPANY
	Wilmington, Delaware 19898 (US)

(72)	Inventors:
	FEVIG, John Matthew Lincoln University, PA 19352-9349 (US) KETTNER, Charles Adrian Wilmington, DE 19803-2709 (US) LEE, Sheng-Lian O. Wilmington, DE 19810-3221 (US) CARINI, David John Wilmington, DE 19803-3107 (US)

(74)	Representative: von Kreisler, Alek, Dipl.-Chem., et al
	Patentanwälte, von Kreisler-Selting-Werner, Bahnhofsvorplatz 1 (Deichmannhaus) D-50667 Köln D-50667 Köln (DE)

(54)	AMIDINO AND GUANIDINO SUBSTITUTED BORONIC ACID INHIBITORS OF TRYPSIN-LIKE ENZYMES