ENCAPSULATION OF NUCLEIC ACIDS WITH CONJUGATES THAT FACILITATE AND TARGET CELLULAR UPTAKE AND GENE EXPRESSION

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EP 0 696 200 A1

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(43)	Date of publication:
	14.02.1996 Bulletin 1996/07

(21)	Application number: 94914823.0

(22)	Date of filing: 19.04.1994

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International Patent Classification (IPC):

C12N 15/ 09^{( . )}
A61K 9/ 52^{( . )}
A61K 47/ 48^{( . )}
C07H 21/ 04^{( . )}
C12N 15/ 82^{( . )}
A61K 38/ 00^{( . )}

A61K 9/ 16^{( . )}
A61K 31/ 70^{( . )}
A61K 48/ 00^{( . )}
C07K 14/ 61^{( . )}
C12N 15/ 87^{( . )}

(86)	International application number:
	PCT/US1994/004239

(87)	International publication number:
	WO 1994/023738 (27.10.1994 Gazette 1994/24)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

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Priority:

19.04.1993 US 19930047536

(71)	Applicant: MEDISORB TECHNOLOGIES INTERNATIONAL L.P.
	Cincinnati, OH 45242 (US)

(72)	Inventors:
	McELLIGOTT, Sandra Gertrude Media, PA 19063 (US) AMOS, Michael David Lebanon, OH 45036 (US)

(74)	Representative: Schlich, George William, et al
	Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)

(54)	ENCAPSULATION OF NUCLEIC ACIDS WITH CONJUGATES THAT FACILITATE AND TARGET CELLULAR UPTAKE AND GENE EXPRESSION