(19)

(11)

EP 0 696 202 A1

(12)

(43) Date of publication: 14.02.1996 Bulletin 1996/07 (21) Application number: 95910515.0 (22) Date of filing: 23.02.1995

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61K 38/ 08( . ) A61P 31/ 12( . ) C07K 7/ 06( . ) A61K 31/ 70( . ) A61K 45/ 06( . ) A61P 31/ 18( . ) (86) International application number: PCT/EP1995/000653 (87) International publication number: WO 1995/023610 (08.09.1995 Gazette 1995/38)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI NL PT SE (30) Priority: 01.03.1994 GB 19940003856 (71) Applicant: PHARMACIA S.p.A. I-20152 Milano (IT)	(72) Inventors: TRIZIO, Domenico I-22070 Cassina Rizzardi (IT) LEONE, Manuela I-15057 Tortona (IT) (74) Representative: Ferrario, Vittorino, et al  Pharmacia & Upjohn S.p.A. Patent and Trademark Department, Viale Pasteur, 10 20014 Nerviano (Milano) 20014 Nerviano (Milano) (IT)