WATER SOLUBLE DERIVATIVES OF CAMPTOTHECIN AND THEIR USE AS ANTITUMOR AGENTS

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EP 0 696 285 A1

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(43)	Date of publication:
	14.02.1996 Bulletin 1996/07

(21)	Application number: 94915931.0

(22)	Date of filing: 28.04.1994

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International Patent Classification (IPC):

A61K^{( . )}
A61K 31/ 47^{( . )}
C07D 317/ 66^{( . )}
C07D 491/ 22^{( . )}

C07D^{( . )}
A61P 35/ 00^{( . )}
C07D 319/ 18^{( . )}

(86)	International application number:
	PCT/US1994/004681

(87)	International publication number:
	WO 1994/025466 (10.11.1994 Gazette 1994/25)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	SI

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Priority:

29.04.1993 US 19930054585
22.06.1993 US 19930081042

(71)	Applicant: GLAXO WELLCOME INC.
	Research Triangle Park, North Carolina 27709 (US)

(72)	Inventors:
	BESTERMAN, Jeffrey, Mark Durham, NC 27713 (US) EVANS, Michael, Glenn Pittsboro, NC 27312 (US) LUZZIO, Michael, Joseph Durham, NC 27707 (US) MYERS, Peter, Leslie Chapel Hill, NC 27514 (US)

(74)	Representative: Gallafent, Alison, et al
	Glaxo Wellcome plc Glaxo House Berkeley Avenue Greenford, Middlesex UB6 0NN Greenford, Middlesex UB6 0NN (GB)

(54)	WATER SOLUBLE DERIVATIVES OF CAMPTOTHECIN AND THEIR USE AS ANTITUMOR AGENTS