BICYCLOPOLYAZAMACROCYCLOPHOSPHONIC ACIDS, THEIR COMPLEXES AND CONJUGATES, FOR USE AS CONTRAST AGENTS, AND PROCESSES FOR THEIR PREPARATION - Patent 0696290

(19)

(11)

EP 0 696 290 A1

(12)

(43)	Date of publication:
	14.02.1996 Bulletin 1996/07

(21)	Application number: 93911136.0

(22)	Date of filing: 06.05.1993

(51)

International Patent Classification (IPC):

A61K 38/ 00^{( . )}
A61K 39/ 44^{( . )}
A61K 51/ 00^{( . )}
C07F 9/ 6561^{( . )}
C07F 15/ 02^{( . )}
C07K 16/ 00^{( . )}

A61K 31/ 675^{( . )}
A61K 49/ 08^{( . )}
A61K 51/ 04^{( . )}
C07F 13/ 00^{( . )}
C07K 14/ 00^{( . )}

(86)	International application number:
	PCT/US1993/004325

(87)	International publication number:
	WO 1994/026754 (24.11.1994 Gazette 1994/26)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI NL SE

(71)	Applicant: THE DOW CHEMICAL COMPANY
	Midland, Michigan 48640 (US)

(72)	Inventors:
	KIEFER, Garry, E. Lake Jackson, TX 77566 (US) SIMON, Jaime Angleton, TX 77515 (US) GARLICH, Joseph, R. Lake Jackson, TX 77566 (US)

(74)	Representative: Raynor, John
	W.H. Beck, Greener & Co 7 Stone Buildings Lincoln's Inn London WC2A 3SZ London WC2A 3SZ (GB)

(54)	BICYCLOPOLYAZAMACROCYCLOPHOSPHONIC ACIDS, THEIR COMPLEXES AND CONJUGATES, FOR USE AS CONTRAST AGENTS, AND PROCESSES FOR THEIR PREPARATION