(19)

(11)

EP 0 698 085 A1

(12)

(43) Date of publication: 28.02.1996 Bulletin 1996/09 (21) Application number: 95912718.0 (22) Date of filing: 03.03.1995

(51) International Patent Classification (IPC):  C12M 3/ 00( . ) C12N 5/ 06( . ) C12M 3/ 04( . ) (86) International application number: PCT/US1995/002686 (87) International publication number: WO 1995/024464 (14.09.1995 Gazette 1995/39)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 11.03.1994 US 19940209660 02.12.1994 US 19940349102 (71) Applicants: BAXTER INTERNATIONAL INC. Deerfield, IL 60015-4633 (US) NORTHWESTERN UNIVERSITY Evanston Illinois 60208-1111 (US)	(72) Inventors: SANDSTROM, Craig Deerfield, IL 60015-3690 (US) PAPOUTSAKIS, E., T. Glenview, IL 60025 (US) MILLER, William, M. Evanston, IL 60201 (US) BENDER, James, G. Lindenhurst, IL 60046 (US) (74) Representative: MacGregor, Gordon  ERIC POTTER CLARKSON St. Mary's Court St. Mary's Gate Nottingham, NG1 1LE Nottingham, NG1 1LE (GB)