(19)

(11)

EP 0 699 210 A1

(12)

(43) Date of publication: 06.03.1996 Bulletin 1996/10 (21) Application number: 95912932.0 (22) Date of filing: 17.03.1995

(51) International Patent Classification (IPC):  A61L 15/ 44( . ) A61K 35/ 16( . ) A61K 38/ 43( . ) A61L 24/ 04( . ) A61P 7/ 04( . ) C07K 14/ 745( . ) A61K 38/ 00( . ) A61K 35/ 14( . ) A61K 38/ 16( . ) A61K 38/ 48( . ) A61L 24/ 10( . ) C07G 99/ 00( . ) C07K 14/ 75( . ) (86) International application number: PCT/US1995/003451 (87) International publication number: WO 1995/025748 (28.09.1995 Gazette 1995/41)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.03.1994 US 19940229158 (71) Applicant: BAXTER INTERNATIONAL INC. Deerfield, Illinois 60015 (US)

(72) Inventors: TSE, Daphne, C. Duarte, CA 91010 (US) MANKARIOUS, Samia, S. Costa Mesa, CA 92626 (US) LIU, Shu-Len Cerritos, CA 90703 (US) THOMAS, William, R. Monarch Beach, CA 92629-4443 (US) ALPERN, Melaine Long Beach, CA 90808 (US) ENOMOTO, Stanley, T. Northridge, CA 91324 (US) GARANCHON, Cataline, M. Northridge, CA 91324 (US) (74) Representative: Bassett, Richard Simon, et al  ERIC POTTER & CLARKSON St. Mary's Court St. Mary's Gate Nottingham NG1 1LE Nottingham NG1 1LE (GB)