(19)

(11)

EP 0 699 239 A1

(12)

(43) Date of publication: 06.03.1996 Bulletin 1996/10 (21) Application number: 94914395.0 (22) Date of filing: 18.04.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 15/ 82( . ) C12N 5/ 10( . ) (86) International application number: PCT/EP1994/001193 (87) International publication number: WO 1994/024293 (27.10.1994 Gazette 1994/24)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE Designated Extension States: SI (30) Priority: 19.04.1993 US 19930049564 (71) Applicants: SANDOZ LTD. CH-4002 Basel (CH) SANDOZ-PATENT-GMBH D-79539 Lörrach (DE) SANDOZ-ERFINDUNGEN Verwaltungsgesellschaft m.b.H. A-1235 Wien (AT)	(72) Inventors: DIETRICH, Paul Shartzer Palo ALto, CA 94303 (US) VAN GRINSVEN, Marinus Quirinus Joseph Marie NL-1602 MA Enkhuizen (NL) GIELEN, Johannes Jacobus Ludgerus NL-1602 GC Enkhuizen (NL) DE HAAS, Johannes Maria NL-1611 CM Bovenkarspel (NL) VAN DRIEL, Roeland NL-1902 DX Castricum (NL)