(19)

(11)

EP 0 700 385 A1

(12)

(43) Date of publication: 13.03.1996 Bulletin 1996/11 (21) Application number: 94918376.0 (22) Date of filing: 24.05.1994

(51) International Patent Classification (IPC):  A61K 31/ 4427( . ) A61K 31/ 445( . ) A61P 9/ 06( . ) C07D 401/ 06( . ) C07D 405/ 12( . ) A61K 31/ 443( . ) A61K 31/ 4468( . ) C07D 211/ 58( . ) C07D 401/ 12( . ) C07D 409/ 12( . ) (86) International application number: PCT/EP1994/001704 (87) International publication number: WO 1994/027967 (08.12.1994 Gazette 1994/27)

(84) Designated Contracting States: BE CH DE FR GB IT LI NL (30) Priority: 26.05.1993 FR 19930006290 29.07.1993 FR 19930009326 (71) Applicant: SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES F-92731 Nanterre Cédex (FR)	(72) Inventors: NADLER, Guy, Marguerite, Marie, Gérard SmithKline Beauregard F-35762 Saint-Grégoire (FR) MORVAN, Marcel, Jean-Marie SmithKline Beecham F-35762 Saint-Grégoire (FR) (74) Representative: Rutter, Keith, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)