(19)

(11)

EP 0 700 436 A1

(12)

(43) Date of publication: 13.03.1996 Bulletin 1996/11 (21) Application number: 94916320.0 (22) Date of filing: 27.05.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 14/ 47( . ) C12Q 1/ 68( . ) C07H 21/ 04( . ) C12N 15/ 12( . ) (86) International application number: PCT/GB1994/001160 (87) International publication number: WO 1994/028129 (08.12.1994 Gazette 1994/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 28.05.1993 GB 19930011130 (71) Applicant: ISIS INNOVATION LIMITED Oxford OX1 3UB (GB)	(72) Inventor: TARIN, David Iffley, Oxford OX4 4EY (GB) (74) Representative: Pennant, Pyers  Stevens, Hewlett & Perkins 1 Serjeants' Inn Fleet Street London EC4Y 1LL London EC4Y 1LL (GB)