(19)

(11)

EP 0 700 523 A1

(12)

(43) Date of publication: 13.03.1996 Bulletin 1996/11 (21) Application number: 94918062.0 (22) Date of filing: 20.05.1994

(51) International Patent Classification (IPC):  A61K 31/ 57( . ) G01N 33/ 50( . ) A61K 35/ 52( . ) G01N 33/ 68( . ) (86) International application number: PCT/US1994/005692 (87) International publication number: WO 1994/028425 (08.12.1994 Gazette 1994/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 21.05.1993 US 19930065903 (71) Applicant: BRIGHAM & WOMEN'S HOSPITAL, INC. Boston, Massachusetts 02115 (US)	(72) Inventors: HILL, Joseph, A. Brookline, MA 02146 (US) ANDERSON, Deborah, J. Brookline, MA 02146 (US) (74) Representative: Jump, Timothy John Simon, et al  Venner Shipley & Co. 20 Little Britain London EC1A 7DH London EC1A 7DH (GB)