(19)

(11)

EP 0 701 573 A1

(12)

(43) Date of publication: 20.03.1996 Bulletin 1996/12 (21) Application number: 94919299.0 (22) Date of filing: 25.05.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07H 21/ 04( . ) C07K 16/ 10( . ) C07K 16/ 46( . ) A61K 39/ 00( . ) A61K 39/ 395( . ) C07K 14/ 11( . ) C07K 16/ 20( . ) C12P 21/ 08( . ) C12R 1/ 91( . ) (86) International application number: PCT/US1994/006090 (87) International publication number: WO 1994/028026 (08.12.1994 Gazette 1994/27)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 28.05.1993 US 19930068895 (71) Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA Oakland, California 94612-3550 (US)	(72) Inventors: ZANETTI, Maurizio La Jolla, CA 92037 (US) BILLETTA, Rosario La Jolla, CA 92037 (US) (74) Representative: Thiel, Christian, Dr. Dipl.-Chem., et al  Schaeferstrasse 18, Postfach 1140 D-44623 Herne D-44623 Herne (DE)