(19)
(11) EP 0 702 683 B8

(12) CORRECTED EUROPEAN PATENT SPECIFICATION
Note: Bibliography reflects the latest situation

(15) Correction information:
Corrected version no 1 (W1 B1)

(48) Corrigendum issued on:
08.09.2004 Bulletin 2004/37

(45) Mention of the grant of the patent:
17.09.2003 Bulletin 2003/38

(21) Application number: 94916373.7

(22) Date of filing: 08.06.1994
(51) International Patent Classification (IPC)7: C07D 473/18
(86) International application number:
PCT/IE1994/000031
(87) International publication number:
WO 1994/029312 (22.12.1994 Gazette 1994/28)

(54)

06-SUBSTITUTED GUANINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND THEIR USE IN TREATING TUMOUR CELLS

O6-SUBSTITUIERTE GUANINEDERIVATE, VERFAHREN ZU IHRE HERSTELLUNG UND IHRE ANWENDUNG FÜR BEHANDLUNG VON TUMORZELLEN

DERIVES DE GUANINE SUBSTITUEE EN POSTION 06, LEUR PROCEDE DE PREPARATION ET LEUR APPLICATION AU TRAITEMENT DES CELLULES TUMORALES

(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
SI

(30) Priority: 08.06.1993 IE 930432
23.05.1994 GB 9410421

(43) Date of publication of application:
27.03.1996 Bulletin 1996/13

(73) Proprietor: Cancer Research Technology Limited
London NW1 4JL (GB)

(72) Inventors:
  • McMURRY, Thomas Brian Hamilton
    Dublin 2 (IE)
  • McELHINNEY, Robert Stanley
    Dublin 2 (IE)
  • McCORMICK, Joan Elizabeth
    Dublin 2 (IE)
  • ELDER, Rhoderick, Hugh c/o Christie Hospital
    Wilmslow Road, Manchester M20 9BX (GB)
  • Kelly, Jane Christie Hospital
    Wilmslow Road, Manchester M20 9BX (GB)
  • MARGISON, Geoffrey, Paul CRC Dept. of Carcinog.
    Wilmslow Road, Manchester M20 9BX (GB)
  • RAFFERTY, Joseph, Anthony CRC Dept. of Carcinog.
    Wilmslow Road, Manchester M20 9BX (GB)
  • WATSON, Amanda, Jean CRC Dept. of Carcinog.
    Wilmslow Road, Manchester M20 9BX (GB)
  • WILLINGTON, Mark, Andrew CRC Dept. of Carcinog.
    Wilmslow Road, Manchester M20 9BX (GB)

(74) Representative: Parkes, Andrew John Aykroyd et al
c/o Tomkins & Co. 5 Dartmouth Road Leeson Park
Dublin 6
Dublin 6 (IE)


(56) References cited: : 
WO-A-91/13898
 DE-A- 2 139 107
   
  • J. MED. CHEM. vol. 37, no. 3 , 4 February 1994 pages 342 - 347 M-Y CHAE ET AL 'Substituted O6-Benzylguanine derivatives and their inactivation of human O6-alkylguanine-DNA transferase' cited in the application
  • J. MED. CHEM. vol. 20, no. 3 , 1977 pages 341 - 344 A.P.MARTINEZ AT AL 'Potential Antitumour agents'
  • J. MED. CHEM. vol. 18, no. 10 , 1975 pages 968 - 973 B. PAUL ET AL 'Inhibiotrs of nucleoside transport'
   
Note: Within nine months from the publication of the mention of the grant of the European patent, any person may give notice to the European Patent Office of opposition to the European patent granted. Notice of opposition shall be filed in a written reasoned statement. It shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention).