RETROVIRAL VECTORS CAPABLE OF EXPRESSING MULTIMERIC PROTEINS FROM MULTIPLE TRANSLATIONAL INITIATION SITES

(19)

(11)

EP 0 706 319 A1

(12)

(43)	Date of publication:
	17.04.1996 Bulletin 1996/16

(21)	Application number: 94909464.0

(22)	Date of filing: 17.01.1994

(51)

International Patent Classification (IPC):

C12N 15/ 09^{( . )}
A61K 35/ 12^{( . )}
A61K 38/ 00^{( . )}
A61P 37/ 06^{( . )}
C12N 5/ 10^{( . )}
C12N 15/ 79^{( . )}
C12P 21/ 02^{( . )}
C12R 1/ 92^{( . )}

A61K 31/ 70^{( . )}
A61K 35/ 76^{( . )}
A61K 48/ 00^{( . )}
C07K 14/ 74^{( . )}
C12N 7/ 01^{( . )}
C12N 15/ 867^{( . )}
C12R 1/ 91^{( . )}

(86)	International application number:
	PCT/US1994/000650

(87)	International publication number:
	WO 1994/024870 (10.11.1994 Gazette 1994/25)

(84)	Designated Contracting States:
	CH DE FR GB GR IE IT LI SE

(30)

Priority:

05.05.1993 US 19930006478

(71)	Applicants:
	BIOTRANSPLANT, INC Charlestown, MA 02129 (US) THE GENERAL HOSPITAL CORPORATION Boston, MA 02114 (US)

(72)	Inventors:
	LE GUERN, Christian, A. Newton Highlands, MA 02161 (US) SEED, Brian Boston, MA 02114 (US) BANERJEE, Papia, T. Lexington, MA 02173 (US)

(74)	Representative: LOUIS, PÖHLAU, LOHRENTZ & SEGETH
	Postfach 3055 D-90014 Nürnberg D-90014 Nürnberg (DE)

(54)	RETROVIRAL VECTORS CAPABLE OF EXPRESSING MULTIMERIC PROTEINS FROM MULTIPLE TRANSLATIONAL INITIATION SITES