(19)

(11)

EP 0 706 375 A1

(12)

(43) Date of publication: 17.04.1996 Bulletin 1996/16 (21) Application number: 94920205.0 (22) Date of filing: 14.06.1994

(51) International Patent Classification (IPC):  A61K 8/ 04( . ) A61K 9/ 16( . ) A61K 47/ 34( . ) C07C 229/ 42( . ) C07C 233/ 63( . ) C07C 235/ 38( . ) C07C 235/ 84( . ) C08G 69/ 10( . ) A61K 8/ 64( . ) A61K 9/ 50( . ) A61Q 13/ 00( . ) C07C 233/ 55( . ) C07C 233/ 87( . ) C07C 235/ 64( . ) C07C 237/ 22( . ) (86) International application number: PCT/US1994/006735 (87) International publication number: WO 1994/028878 (22.12.1994 Gazette 1994/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 14.06.1993 US 19930076803 (71) Applicant: Emisphere Technologies, Inc. Hawthorne, NY 10532 (US)	(72) Inventors: MILSTEIN, Sam J. Larchmont, NY 10801 (US) KANTOR, Martin L. Mamaroneck, NY 10503 (US) (74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät  Maximilianstrasse 58 D-80538 München D-80538 München (DE)