(19)

(11)

EP 0 706 391 A1

(12)

(43) Date of publication: 17.04.1996 Bulletin 1996/16 (21) Application number: 94921320.0 (22) Date of filing: 17.06.1994

(51) International Patent Classification (IPC):  A61K 33/ 30( . ) C07C 259/ 06( . ) (86) International application number: PCT/US1994/006878 (87) International publication number: WO 1995/000140 (05.01.1995 Gazette 1995/02)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 18.06.1993 IL 19930106064 (71) Applicant: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM Jerusalem 91042 (IL)	(72) Inventors: CHEVION, Mordechai 97230 Jerusalem (IL) BERENSHTEIN, Eduard Pisgat Zeev 97534 Jerusalem (IL) (74) Representative: Ablewhite, Alan James, et al  MARKS & CLERK, 57/60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)