(19)

(11)

EP 0 707 484 A1

(12)

(43) Date of publication: 24.04.1996 Bulletin 1996/17 (21) Application number: 94921465.0 (22) Date of filing: 05.07.1994

(51) International Patent Classification (IPC):  A61K 31/ 425( . ) A61K 31/ 80( . ) A61K 33/ 08( . ) A61P 1/ 04( . ) A61K 31/ 715( . ) A61K 33/ 00( . ) A61K 33/ 10( . ) (86) International application number: PCT/US1994/007519 (87) International publication number: WO 1995/001795 (19.01.1995 Gazette 1995/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 06.07.1993 US 19930087937 (71) Applicants: MERCK & CO. INC. Rahway New Jersey 07065-0900 (US) McNEIL-PPC, INC. Milltown New Jersey 08850 (US)	(72) Inventors: SIMS, Robert T. Holicong, PA 18928 (US) SLIVKA, William Philadelphia, PA 19118 (US) (74) Representative: Cole, William Gwyn  European Patent Department Merck & Co., Inc. Terlings Park Eastwick Road Harlow Essex CM20 2QR Harlow Essex CM20 2QR (GB)