(19)

(11)

EP 0 707 492 A1

(12)

(43) Date of publication: 24.04.1996 Bulletin 1996/17 (21) Application number: 94923918.0 (22) Date of filing: 05.07.1994

(51) International Patent Classification (IPC):  A61K 38/ 46( . ) A61K 31/ 215( . ) A61K 31/ 425( . ) A61K 31/ 80( . ) A61K 31/ 16( . ) A61K 31/ 415( . ) A61K 31/ 445( . ) A61K 38/ 47( . ) (86) International application number: PCT/US1994/007520 (87) International publication number: WO 1995/001803 (19.01.1995 Gazette 1995/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 06.07.1993 US 19930087590 (71) Applicants: MERCK & CO. INC. Rahway New Jersey 07065-0900 (US) McNEILL-PPC, INC. Milltown, NJ 08850 (US)	(72) Inventors: SIMS, Robert T. Holicong, PA 18928 (US) SLIVKA, William Philadelphia, PA 19118 (US) (74) Representative: Cole, William Gwyn  European Patent Department Merck & Co., Inc. Terlings Park Eastwick Road Harlow Essex CM20 2QR Harlow Essex CM20 2QR (GB)