(19)

(11)

EP 0 707 585 A1

(12)

(43) Date of publication: 24.04.1996 Bulletin 1996/17 (21) Application number: 94916370.0 (22) Date of filing: 16.06.1994

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) A61K 31/ 435( . ) A61P 35/ 00( . ) C07D 221/ 00( . ) C07D 471/ 04( . ) A61K 31/ 4162( . ) A61K 31/ 437( . ) A61P 43/ 00( . ) C07D 231/ 00( . ) (86) International application number: PCT/IB1994/000156 (87) International publication number: WO 1995/001980 (19.01.1995 Gazette 1995/04)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 06.07.1993 US 19930088292 (71) Applicant: PFIZER INC. New York, N.Y. 10017 (US)	(72) Inventor: DUPLANTIER, Allen, Jacob Ledyard, CT 06339 (US) (74) Representative: Wood, David John  PFIZER LIMITED, Ramsgate Road Sandwich, Kent CT13 9NJ Sandwich, Kent CT13 9NJ (GB)