(19)
(11)
EP 0 708 655 A1
(12)
(43)
Date of publication:
01.05.1996
Bulletin 1996/18
(21)
Application number:
94914048.0
(22)
Date of filing:
06.04.1994
(51)
International Patent Classification (IPC):
C12N
15/
09
( . )
A61P
3/
08
( . )
A61P
35/
00
( . )
C07K
14/
47
( . )
C12N
15/
12
( . )
A61K
38/
00
( . )
A61K
38/
27
( . )
A61P
3/
10
( . )
C07K
14/
46
( . )
C12N
1/
21
( . )
C12P
21/
02
( . )
C12R
1/
19
( . )
(86)
International application number:
PCT/US1994/003755
(87)
International publication number:
WO 1994/022466
(
13.10.1994
Gazette 1994/23)
(84)
Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
(30)
Priority:
07.04.1993
US 19930045265
(71)
Applicant:
AMGEN BOULDER INC.
Boulder, Colorado 80301 (US)
(72)
Inventors:
COX, George, N.
Louisville, CO 80027 (US)
RUSSELL, Deborah, A.
Boulder, CO 80303 (US)
(74)
Representative:
Vossius, Volker, Dr.
Dr. Volker Vossius, Patentanwaltskanzlei - Rechtsanwaltskanzlei, Holbeinstrasse 5
D-81679 München
D-81679 München (DE)
(54)
METHODS OF USING INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS