(19)

(11)

EP 0 708 658 A1

(12)

(43) Date of publication: 01.05.1996 Bulletin 1996/18 (21) Application number: 94915386.0 (22) Date of filing: 15.04.1994

(51) International Patent Classification (IPC):  C07K 14/ 045( . ) A61K 39/ 00( . ) C12N 15/ 861( . ) (86) International application number: PCT/US1994/004180 (87) International publication number: WO 1994/023744 (27.10.1994 Gazette 1994/24)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.04.1993 US 19930048978 (71) Applicants: THE WISTAR INSTITUTE OF ANATOMY & BIOLOGY Philadelpia, PA 19104-4268 (US) THE UNITED STATES GOVERNMENT, as represented by THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Washington, DC 20231 (US)

(72) Inventors: PLOTKIN, Stanley A. F-75016 Paris (FR) RICCIARDI, Robert P. Glen Mills, PA 19342 (US) GONCZOL, Eva 1030 E. Lancaster Avenue Rosemont, PA 19010 (US) BERENCSI, Klara 1030 E. Lancaster Avenue Rosemont, PA 19010 (US) RANDO, Robert F. The Woodlands, TX 77381 (US) (74) Representative: Hale, Stephen Geoffrey  J.Y. & G.W. Johnson Furnival House 14/18 High Holborn London WC1V 6DE London WC1V 6DE (GB)