(19)

(11)

EP 0 708 782 A1

(12)

(43) Date of publication: 01.05.1996 Bulletin 1996/18 (21) Application number: 94922588.0 (22) Date of filing: 15.07.1994

(51) International Patent Classification (IPC):  C12Q 1/ 68( . ) (86) International application number: PCT/US1994/008023 (87) International publication number: WO 1995/002605 (26.01.1995 Gazette 1995/05)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 15.07.1993 US 19930093198 (71) Applicant: THE FLORIDA STATE UNIVERSITY Tallahassee, FL 32306 (US)	(72) Inventor: DE KLOET, Siwo, R. Tallahassee, FL 32308 (US) (74) Representative: Findlay, Alice Rosemary, et al  Lloyd Wise, Tregear & Co., Commonwealth House, 1-19 New Oxford Street London WC1A 1LW London WC1A 1LW (GB)