| (84) |
Designated Contracting States: |
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AT BE CH DE FR GB IT LI |
| (30) |
Priority: |
10.07.1993 EP 93111059
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| (43) |
Date of publication of application: |
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01.05.1996 Bulletin 1996/18 |
| (73) |
Proprietor: BIOGNOSTIK GESELLSCHAFT FÜR BIOMOLEKULARE DIAGNOSTIK mbH |
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D-37079 Göttingen (DE) |
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| (72) |
Inventors: |
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- SCHLINGENSIEPEN, Georg-F.
D-37073 Göttingen (DE)
- SCHLINGENSIEPEN, Reimar
D-37073 Göttingen (DE)
- SCHLINGENSIEPEN, Karl-Hermann
D-37120 Göttingen (DE)
- BRYSCH, Wolfgang
D-37073 Göttingen (DE)
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| (74) |
Representative: Meyers, Hans-Wilhelm, Dr.Dipl.-Chem. et al |
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Patentanwälte
von Kreisler-Selting-Werner
Postfach 10 22 41
50462 Köln
50462 Köln (DE) |
| (56) |
References cited: :
EP-A- 0 305 929
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WO-A-92/15680
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- WICKSTROM, E. 'Prospects for antisense nucleic acid therapy of cancer and AIDS'; 1991,
WILEY-LISS, Inc., NEW YORK, USA; pages 83-114, MERCOLA, D. cited in the application
- ERICKSON, R. & IZANT, J. 'Gene regulation: biology of antisense RNA and DNA'; 1992
RAVEN PRESS, Ltd., NEW YORK, USA; pages 285-293, BRADLEY, M. et al.
- NATURE, vol.332, 10 March 1988, LONDON GB pages 166 - 171 ANGEL, P. ET AL. 'Oncogene
jun encodes a sequence-specific trans-activator similar to AP-1'
- JOURNAL OF BIOLOGICAL CHEMISTRY, vol.267, no.27, 25 September 1992, BALTIMORE, MD
US pages 19665 - 19672 NICOLAIDES, N. ET AL. 'The Jun family members, c-jun and junD,
transactivate the human c-myb promoter via an Ap1-like element'
- PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol.32, March 1991 page
303 SCHLINGENSIEPEN, K.-H. & BRYSCH, W. 'Proto-oncogenes c-jun and jun-B have opposite
effects on cell proliferation' cited in the application & 82nd Annual Meeting of the
American Association for Cancer Research; May 15-18, 1991; HOUSTON, USA
- JOURNAL OF CELLULAR BIOCHEMISTRY, vol.17A, 1993 page 208 SCHLINGENSIEPEN, K.-H. ET
AL. 'Function of junB and c-jun in the differentiation of neurons and PC-12 tumor
cells' cited in the application & Keystone Symposia on Molecular & Cellular Biology;
January 9-31, 1993
- BIOMEDICINE & PHARMACOTHERAPY, vol.46, no.5-7, 1992 page 257 SCHLINGENSIEPEN, K.-H.
& BRYSCH, W. 'Specific inhibition of different jun genes either inhibits or stimulates
cell differentiation' cited in the application & 5th International Congress on Differentiation
Therapy; September 2-5, 1992; VILLASIMIUS, Italy
- DEVELOPMENTAL GENETICS, vol.14, 20 September 1993 pages 305 - 312 SCHLINGENSIEPEN,
K.-H. ET AL. 'Opposite functions of jun-B and c-jun in growth regulation and neuronal
differentiation' cited in the application
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