(19)

(11)

EP 0 708 833 A1

(12)

(43) Date of publication: 01.05.1996 Bulletin 1996/18 (21) Application number: 94920039.0 (22) Date of filing: 25.05.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 1/ 19( . ) C12N 9/ 50( . ) C12R 1/ 19( . ) C12R 1/ 92( . ) C07K 16/ 08( . ) C12N 1/ 21( . ) C12N 15/ 57( . ) C12R 1/ 865( . ) (86) International application number: PCT/US1994/005920 (87) International publication number: WO 1994/029456 (22.12.1994 Gazette 1994/28)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 08.06.1993 US 19930073819 23.05.1994 US 19940245390 (71) Applicant: Abbott Laboratories Abbott Park, Illinois 60064-3500 (US)

(72) Inventors: STEFFY, Kevin R. Buffalo Grove, IL 60089 (US) KATI, Warren M. Gurnee, IL 60031 (US) KATZ, Leonard Wheeling, IL 60090 (US) McGONIGAL, Thomas P. Waukegan, IL 60087 (US) SARTHY, Aparna V. Waukegan, IL 60087 (US) SCHOEN, Sharon E. Chicago, IL 60626 (US) (74) Representative: Modiano, Guido, Dr.-Ing., et al  Modiano, Josif, Pisanty & Staub, Baaderstrasse 3 D-80469 München D-80469 München (DE)