(19)

(11)

EP 0 710 115 A1

(12)

(43) Date of publication: 08.05.1996 Bulletin 1996/19 (21) Application number: 94923169.0 (22) Date of filing: 02.06.1994

(51) International Patent Classification (IPC):  A61K 38/ 16( . ) A61P 7/ 08( . ) A61K 38/ 42( . ) (86) International application number: PCT/US1994/006030 (87) International publication number: WO 1995/003068 (02.02.1995 Gazette 1995/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 23.07.1993 US 19930097258 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)	(72) Inventor: HUGHES, George, S., Jr. Kalamazoo, MI 49002 (US) (74) Representative: Perry, Robert Edward, et al  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)