(19)

(11)

EP 0 711 356 A1

(12)

(43) Date of publication: 15.05.1996 Bulletin 1996/20 (21) Application number: 95920665.0 (22) Date of filing: 25.05.1995

(51) International Patent Classification (IPC):  C12Q 1/ 68( . ) (86) International application number: PCT/US1995/006696 (87) International publication number: WO 1995/033070 (07.12.1995 Gazette 1995/52)

(84) Designated Contracting States: DE DK IT (30) Priority: 26.05.1994 US 19940249394 (71) Applicant: NEW YORK MEDICAL COLLEGE Valhalla, NY 10595 (US)	(72) Inventors: DARZYNKIEWICZ, Zbigniew, D. Chappaqua, NY 10514 (US) LI, Xun Yorktown Hights, NY 10598 (US) TRAGANOS, Frank, N. New York, NY 10021 (US) MELAMED, Myron, R. Dobbs Ferry, NY 10522 (US) (74) Representative: Baldock, Sharon Claire  Boult, Wade & Tennant 27 Furnival Street London EC4A 1PQ London EC4A 1PQ (GB)