(19)

(11)

EP 0 716 570 A1

(12)

(43) Date of publication: 19.06.1996 Bulletin 1996/25 (21) Application number: 94928018.0 (22) Date of filing: 06.09.1994

(51) International Patent Classification (IPC):  A61K 35/ 28( . ) C12N 5/ 22( . ) C12N 5/ 0789( . ) A61K 48/ 00( . ) (86) International application number: PCT/US1994/010033 (87) International publication number: WO 1995/006409 (09.03.1995 Gazette 1995/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 03.09.1993 US 19930116825 (71) Applicant: SYSTEMIX, INC. Palo Alto, California 94304 (US)	(72) Inventor: MULE, James Palo Alto, CA 94303 (US) (74) Representative: Goldin, Douglas Michael  J.A. KEMP & CO. 14, South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)