(19)

(11)

EP 0 716 659 A1

(12)

(43) Date of publication: 19.06.1996 Bulletin 1996/25 (21) Application number: 94929787.0 (22) Date of filing: 02.09.1994

(51) International Patent Classification (IPC):  C07K 14/ 705( . ) A61K 38/ 00( . ) C07K 16/ 18( . ) (86) International application number: PCT/US1994/010261 (87) International publication number: WO 1995/006660 (09.03.1995 Gazette 1995/11)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 02.09.1993 US 19930115918 (60) Divisional application: 07075129.2 / 1808439 (71) Applicant: Fred Hutchinson Cancer Research Center Seattle Washington 98104 (US)	(72) Inventors: CARTER, William, G. Winslow, WA 98110 (US) GIL, Susana, G. Seattle, WA 98122 (US) RYAN, Maureen, C. Seattle, WA 98118 (US) (74) Representative: Bizley, Richard Edward  Hepworth, Lawrence, Bryer & Bizley Merlin House Falconry Court Baker's Lane Epping Essex CM16 5DQ Epping Essex CM16 5DQ (GB)