(19)

(11)

EP 0 717 622 A1

(12)

(43) Date of publication: 26.06.1996 Bulletin 1996/26 (21) Application number: 94925100.0 (22) Date of filing: 22.07.1994

(51) International Patent Classification (IPC):  C07D 221/ 20( . ) A61K 31/ 403( . ) A61P 31/ 12( . ) C07D 209/ 54( . ) A61K 31/ 40( . ) A61K 31/ 435( . ) A61P 37/ 04( . ) (86) International application number: PCT/US1994/008274 (87) International publication number: WO 1995/003049 (02.02.1995 Gazette 1995/06)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 23.07.1993 GB 19930015351 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventor: BADGER, Alison Mary Bryn Mawr, PA 19010 (US) (74) Representative: Summersell, Richard John  SmithKline Beecham Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)