(19)

(11)

EP 0 719 283 A1

(12)

(43) Date of publication: 03.07.1996 Bulletin 1996/27 (21) Application number: 94924931.0 (22) Date of filing: 26.08.1994

(51) International Patent Classification (IPC):  C12P 21/ 00( . ) A61K 38/ 00( . ) C07K 1/ 16( . ) C07K 1/ 22( . ) C07K 14/ 50( . ) A61K 35/ 14( . ) A61P 43/ 00( . ) C07K 1/ 18( . ) C07K 14/ 475( . ) C12R 1/ 91( . ) (86) International application number: PCT/GB1994/001868 (87) International publication number: WO 1995/006063 (02.03.1995 Gazette 1995/10)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.08.1993 GB 19930017771 (71) Applicant: CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED London NW1 4JL (GB)	(72) Inventors: JONES, Sarah, Jane Fife KY16 9NS (GB) MOLINEUX, Graham Moorpark, CA 93021 (US) DEXTER, Michael, Thomas Withington, Manchester M20 9BX (GB) FRIEDENSTEIN, Alexander, The Gamaleya Inst. for Sciences, Gamaleya Str 18, Moscow, D-98 (RU) (74) Representative: Kiddle, Simon John, et al  Mewburn Ellis, York House, 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)