(19)

(11)

EP 0 720 486 A1

(12)

(43) Date of publication: 10.07.1996 Bulletin 1996/28 (21) Application number: 94929205.0 (22) Date of filing: 15.09.1994

(51) International Patent Classification (IPC):  C07K 14/ 705( . ) C07K 16/ 28( . ) A61K 38/ 00( . ) C07K 14/ 78( . ) C07K 19/ 00( . ) (86) International application number: PCT/US1994/010395 (87) International publication number: WO 1995/007717 (23.03.1995 Gazette 1995/13)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 15.09.1993 US 19930122228 (71) Applicants: EMORY UNIVERSITY Atlanta, GA 30322 (US) GEORGIA TECH RESEARCH CORPORATION Atlanta, GA 30332-0415 (US)	(72) Inventors: SWERLICK, Robert A. Atlanta, GA 30345 (US) ECKMAN, James R. Decatur, GA 30033 (US) WICK, Timothy M. Atlanta, GA 30329 (US) (74) Representative: Ruffles, Graham Keith  MARKS & CLERK, 57-60 Lincoln's Inn Fields London WC2A 3LS London WC2A 3LS (GB)