(19)

(11)

EP 0 721 350 A1

(12)

(43) Date of publication: 17.07.1996 Bulletin 1996/29 (21) Application number: 94925693.0 (22) Date of filing: 28.07.1994

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 395( . ) C07K 16/ 00( . ) C12N 5/ 10( . ) A61K 38/ 00( . ) A61K 31/ 70( . ) A61K 48/ 00( . ) C07K 16/ 10( . ) C12N 15/ 13( . ) (86) International application number: PCT/US1994/008448 (87) International publication number: WO 1995/003832 (09.02.1995 Gazette 1995/07)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 30.07.1993 US 19930099870 (71) Applicant: THOMAS JEFFERSON UNIVERSITY Philadelphia Pennsylvania 19107 (US)	(72) Inventors: DUAN, Lingxun Philadelphia, PA 19111 (US) POMERANTZ, Roger Chalfont, PA 18914 (US) (74) Representative: Hallybone, Huw George  CARPMAELS AND RANSFORD 43 Bloomsbury Square London WC1A 2RA London WC1A 2RA (GB)