(19)
(11) EP 0 722 339 A1

(12)

(43) Date of publication:
24.07.1996 Bulletin 1996/30

(21) Application number: 94930665.0

(22) Date of filing: 07.10.1994
(51) International Patent Classification (IPC): 
C12N 15/ 09( . )
A61P 31/ 04( . )
C12N 1/ 21( . )
C12P 21/ 02( . )
A61K 39/ 106( . )
C07K 14/ 28( . )
C12N 15/ 63( . )
C12R 1/ 63( . )
(86) International application number:
PCT/US1994/011424
(87) International publication number:
WO 1995/010300 (20.04.1995 Gazette 1995/17)
(84) Designated Contracting States:
AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 08.10.1993 US 19930133438
08.10.1993 US 19930133439

(71) Applicant: THE UNIVERSITY OF MARYLAND AT BALTIMORE
Baltimore Maryland 21201 (US)

(72) Inventors:
  • KAPER, James B.
    Columbia, MD 21045 (US)
  • LEVINE, Myron M.
    Columbia, MD 21044 (US)

(74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät 
Maximilianstrasse 58
80538 München
80538 München (DE)

   


(54) $i(VIBRIO CHOLERAE) 01 (CVD111) AND NON-01 (CVD112 AND CVD112RM) SEROGROUP VACCINE STRAINS AND METHODS OF MAKING SAME