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(11)

EP 0 722 447 A1

(12)

(43) Date of publication: 24.07.1996 Bulletin 1996/30 (21) Application number: 94927783.0 (22) Date of filing: 27.09.1994

(51) International Patent Classification (IPC):  C07D 477/ 00( . ) A61K 31/ 40( . ) C07D 477/ 20( . ) A61K 31/ 397( . ) A61P 31/ 04( . ) (86) International application number: PCT/JP1994/001588 (87) International publication number: WO 1995/010520 (20.04.1995 Gazette 1995/17)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU NL PT SE (30) Priority: 08.10.1993 GB 19930020816 (71) Applicant: FUJISAWA PHARMACEUTICAL CO., LTD. Osaka-shi Osaka 541 (JP)

(72) Inventors: MURATA, Masayoshi 7-17, Higashitokiwadai 7-chome Toyono-gun Osaka 563-01 (JP) TSUTSUMI, Hideo 16-3-301, Yuhigaoka 2-chome Osaka 560 (JP) MATSUDA, Keiji 14-18, Kosobecho 3-chome Osaka 569 (JP) HATTORI, Kohji 1-7-1-915, Sumiregaoka Hyogo 665 (JP) NAKAJIMA, Takashi 2-21-1-1208, Kamishinden Osaka 565 (JP) (74) Representative: Türk, Dietmar, Dr. rer. nat.  Türk, Gille, Hrabal, Leifert Patentanwälte Brucknerstrasse 20 40593 Düsseldorf 40593 Düsseldorf (DE)