BOROPEPTIDE INHIBITORS OF THROMBIN WHICH CONTAIN A SUBSTITUTED PYRROLIDINE RING - Patent 0722449

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EP 0 722 449 A1

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(43)	Date of publication:
	24.07.1996 Bulletin 1996/30

(21)	Application number: 94929943.0

(22)	Date of filing: 06.10.1994

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International Patent Classification (IPC):

C07D 207/ 26^{( . )}
C07F 9/ 572^{( . )}
A61K 38/ 00^{( . )}

C07F 5/ 02^{( . )}
C07K 5/ 06^{( . )}

(86)	International application number:
	PCT/US1994/011049

(87)	International publication number:
	WO 1995/009859 (13.04.1995 Gazette 1995/16)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE

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Priority:

07.10.1993 US 19930133250
20.10.1993 US 19930139443

(71)	Applicant: THE DU PONT MERCK PHARMACEUTICAL COMPANY
	Wilmington, Delaware 19898 (US)

(72)	Inventors:
	PACOFSKY, Gregory, James Raleigh, NC 27604 (US) PRUITT, James, Russell Landenberg, PA 19350 (US) WEBER, Patricia, Carol Kennett Square, PA 19348-2705 (US)

(74)	Representative: von Kreisler, Alek, Dipl.-Chem., et al
	Patentanwälte, von Kreisler-Selting-Werner, Bahnhofsvorplatz 1 (Deichmannhaus) 50667 Köln 50667 Köln (DE)

(54)	BOROPEPTIDE INHIBITORS OF THROMBIN WHICH CONTAIN A SUBSTITUTED PYRROLIDINE RING