SUBSTITUTED UREA AND ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS - Patent 0723438

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(11)

EP 0 723 438 A1

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(43)	Date of publication:
	31.07.1996 Bulletin 1996/31

(21)	Application number: 94927761.0

(22)	Date of filing: 03.10.1994

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International Patent Classification (IPC):

C07D 277/ 20^{( . )}
A61K 31/ 13^{( . )}
A61K 31/ 155^{( . )}
A61K 31/ 165^{( . )}
A61K 31/ 215^{( . )}
A61K 31/ 426^{( . )}
A61P 3/ 00^{( . )}
A61P 9/ 10^{( . )}
A61P 43/ 00^{( . )}
C07C 275/ 26^{( . )}
C07C 275/ 70^{( . )}
C07C 335/ 30^{( . )}
C07D 213/ 75^{( . )}
C07D 277/ 42^{( . )}

A61K 31/ 00^{( . )}
A61K 31/ 135^{( . )}
A61K 31/ 16^{( . )}
A61K 31/ 195^{( . )}
A61K 31/ 425^{( . )}
A61K 31/ 44^{( . )}
A61P 9/ 00^{( . )}
A61P 25/ 28^{( . )}
C07C 275/ 16^{( . )}
C07C 275/ 28^{( . )}
C07C 281/ 06^{( . )}
C07C 335/ 32^{( . )}
C07D 277/ 18^{( . )}

(86)	International application number:
	PCT/GB1994/002138

(87)	International publication number:
	WO 1995/009619 (13.04.1995 Gazette 1995/16)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
	Designated Extension States:
	LT SI

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Priority:

04.10.1993 US 19930131794
01.06.1994 EP 19940303939

(71)	Applicant: THE WELLCOME FOUNDATION LIMITED
	Greenford, Middlesex UB6 0NN (GB)

(72)	Inventors:
	OPLINGER, Jeffrey Alan Cary, NC 27513 (US) SHEARER, Barry George Cary, NC 27513 (US) BIGHAM, Eric Cleveland Chapel Hill, NC 27514 (US) FURFINE, Eric Steven Durham, NC 27707 (US) GARVEY, Edward Patrick Chapel Hill, NC 27516 (US)

(74)	Representative: Stott, Michael John, et al
	Glaxo Wellcome plc, Glaxo Wellcome House, Berkeley Avenue Greenford, Middlesex UB6 0NN Greenford, Middlesex UB6 0NN (GB)

(54)	SUBSTITUTED UREA AND ISOTHIOUREA DERIVATIVES AS NO SYNTHASE INHIBITORS