(19)

(11)

EP 0 723 446 A1

(12)

(43) Date of publication: 31.07.1996 Bulletin 1996/31 (21) Application number: 94930547.0 (22) Date of filing: 30.09.1994

(51) International Patent Classification (IPC):  A61K 31/ 445( . ) (86) International application number: PCT/US1994/011155 (87) International publication number: WO 1995/010278 (20.04.1995 Gazette 1995/17)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 15.10.1993 US 19930137545 (71) Applicant: HOECHST MARION ROUSSEL, INC. Cincinnati OH 45215-6300 (US)	(72) Inventor: McNUTT, Bruce E. Cincinnati, OH 45249 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)