(19)

(11)

EP 0 724 440 A1

(12)

(43) Date of publication: 07.08.1996 Bulletin 1996/32 (21) Application number: 94926534.0 (22) Date of filing: 19.08.1994

(51) International Patent Classification (IPC):  A61K 31/ 435( . ) A61P 15/ 00( . ) A61P 43/ 00( . ) A61P 13/ 02( . ) A61P 35/ 00( . ) C07D 221/ 10( . ) (86) International application number: PCT/US1994/009382 (87) International publication number: WO 1995/005821 (02.03.1995 Gazette 1995/10)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 20.08.1993 GB 19930017314 (71) Applicant: SMITHKLINE BEECHAM CORPORATION King of Prussia, PA 19406-0939 (US)	(72) Inventors: HOLT, Dennis Alan Stow, MA (US) YAMASHITA, Dennis Shinji King of Prussia, PA 19406 (US) YEN, Hwa-Kwo Malvern, PA 19355 (US) (74) Representative: Summersell, Richard John  SmithKline Beecham Corporate Intellectual Property SB House Great West Road Brentford, Middlesex TW8 9BD Brentford, Middlesex TW8 9BD (GB)