(19)

(11)

EP 0 724 573 A1

(12)

(43) Date of publication: 07.08.1996 Bulletin 1996/32 (21) Application number: 94928624.0 (22) Date of filing: 21.09.1994

(51) International Patent Classification (IPC):  C07D 239/ 34( . ) A61P 29/ 00( . ) C07D 239/ 46( . ) C07D 239/ 56( . ) A61K 31/ 505( . ) C07D 239/ 36( . ) C07D 239/ 52( . ) C07F 9/ 6512( . ) (86) International application number: PCT/US1994/010571 (87) International publication number: WO 1995/011235 (27.04.1995 Gazette 1995/18)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: LT SI (30) Priority: 20.10.1993 US 19930139078 03.12.1993 US 19930161676 (71) Applicant: THE UPJOHN COMPANY Kalamazoo, Michigan 49001 (US)	(72) Inventors: NUGENT, Richard, Allen Galesburg, MI 49053 (US) SCHLACHTER, Stephen, T. Kalamazoo, MI 49008 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)