(19)

(11)

EP 0 725 652 A1

(12)

(43) Date of publication: 14.08.1996 Bulletin 1996/33 (21) Application number: 94929888.0 (22) Date of filing: 27.09.1994

(51) International Patent Classification (IPC):  A61K 38/ 22( . ) (86) International application number: PCT/US1994/010879 (87) International publication number: WO 1995/009646 (13.04.1995 Gazette 1995/16)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.10.1993 US 19930132859 10.06.1994 US 19940258227 (71) Applicant: THE GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER Washington, DC 20037 (US)	(72) Inventors: GOLDSTEIN, Allan L. Bethesda, MD 20814 (US) FAGARASAN, Mirela O., Apartment 608 North Washington, DC 20037 (US) (74) Representative: Popp, Eugen, Dr., et al  MEISSNER, BOLTE & PARTNER Widenmayerstrasse 48 80538 München 80538 München (DE)