(19)

(11)

EP 0 725 698 A1

(12)

(43) Date of publication: 14.08.1996 Bulletin 1996/33 (21) Application number: 94930610.0 (22) Date of filing: 05.10.1994

(51) International Patent Classification (IPC):  A61C 5/ 04( . ) B22F 1/ 00( . ) B22F 3/ 22( . ) C22C 9/ 00( . ) C22C 47/ 14( . ) A61K 6/ 04( . ) B22F 1/ 02( . ) C22C 1/ 10( . ) C22C 47/ 00( . ) C23G 1/ 00( . ) (86) International application number: PCT/US1994/011312 (87) International publication number: WO 1995/010379 (20.04.1995 Gazette 1995/17)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 08.10.1993 US 19930133316 04.10.1994 US 19940317729 (71) Applicants: THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF COMMERCE,National Institute of Standards & Technology Gaithersburg, MD 20899 (US) Beane, Glenn L. Plymouth, NH 03264 (US) AMERICAN DENTAL ASSOCIATION HEALTH FOUNDATION Chicago, IL 60611-2678 (US)

(72) Inventors: BEANE, Glenn L., R.F.D. 3 Plymouth, NH 03264 (US) LASHMORE, David, S. Frederick, MD 21701 (US) DARIEL, Moshe, P. Rockville, MD 20852 (US) JOHNSON, Christian, E. Middleton, MD 21769 (US) RATZKER, Menahem, B. Silver Spring, MD 20902 (US) GIUSEPPETTI, Anthony, A. Frederick, MD 21701 (US) EICHMILLER, Frederick, C. Ijamsville, MD 21754 (US) KELLEY, David, R. Martinsburg, WV 25401 (US) (74) Representative: Walton, Seán Malcolm, et al  Mewburn Ellis, York House, 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)