(19)

(11)

EP 0 725 828 A1

(12)

(43) Date of publication: 14.08.1996 Bulletin 1996/33 (21) Application number: 95901140.0 (22) Date of filing: 04.11.1994

(51) International Patent Classification (IPC):  A61K 38/ 17( . ) A61K 48/ 00( . ) A61K 39/ 00( . ) (86) International application number: PCT/US1994/012701 (87) International publication number: WO 1995/012681 (11.05.1995 Gazette 1995/20)

(84) Designated Contracting States: AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.11.1993 US 19930147285 (71) Applicants: NEW YORK UNIVERSITY New York, NY 10016 (US) UNIVERSITA DEGLI STUDI "G., D'ANNUNZIO"-CHIETI I-66100 Cheti (IT)	(72) Inventors: IACOBELLI, Stefano I-00198 Roma (IT) JALLAL, Bahija Redwood City, CA 94063-4720 (US) NATOLI, Clara I-00141 Roma (IT) POWELL, Jeff Sunnyvale, CA 94089 (US) ULLRICH, Axel D-8000 Munich 40 (DE) (74) Representative: Viering, Jentschura & Partner  Postfach 22 14 43 80504 München 80504 München (DE)